Drug Interactions: Antidepressants and Anesthetics
The interaction between antidepressants and anesthetics is not only limited to side effects, but also to changes in the effectiveness of medications. For example, antidepressants can alter the body’s response to anesthetics, either by decreasing or increasing their effectiveness.
An important aspect is the metabolism of drugs. Some antidepressants can inhibit or induce liver enzymes responsible for metabolizing anesthetics. This means that the duration and intensity of the anesthetic effect can be unpredictable, requiring dosage adjustments to ensure the efficacy and safety of the procedure.
Additionally, the interaction between these drugs may influence postoperative recovery. For example, patients using antidepressants may experience a slower recovery of consciousness or a greater sensitivity to side effects such as nausea and vomiting after surgery.
Given the complexity of these interactions, preoperative evaluation becomes even more essential. This is the time when the anesthesiologist should review the patient’s medical and pharmacological history, adjusting the anesthetic plan as necessary to mitigate risks and ensure safe and effective anesthesia.
